| Date | Day | Opponent | Location | TV | Time/Result |
| 11/02/05 | Wed | BELLARMINE (Exhibition) | FREEDOM HALL | WHAS | W, 70-63 |
| 11/19/05 | Sat | TENNESSEE-MARTIN | FREEDOM HALL | WHAS | 12:05 PM |
| 11/20/05 | Sun | SOUTHERN INDIANA (Exhibition) | FREEDOM HALL | WHAS | 5:05 PM |
| 12/03/05 | Sat | PRAIRIE VIEW A&M (Colonial Classic) | FREEDOM HALL | WBKI | 1:00 PM |
| 12/04/05 | Sun | ARKANSAS STATE (Colonial Classic) | FREEDOM HALL | WHAS | 7:05 PM |
| 12/05/05 | Mon | RICHMOND (Colonial Classic) | FREEDOM HALL | WHAS | 7:05 PM |
| 12/10/05 | Sat | AKRON | FREEDOM HALL | WHAS | 1:05 PM |
| 12/13/05 | Tue | CHICAGO STATE | FREEDOM HALL | WHAS | 7:05 PM |
| 12/17/05 | Sat | at Kentucky | Lexington, Ky. | CBS | 2:00 PM |
| 12/20/05 | Tue | MIDDLE TENNESSEE STATE (Billy Minardi Classic) | FREEDOM HALL | WHAS | 7:05 PM |
| 12/21/05 | Wed | COLL. OF CHARLESTON/FLORIDA ATLANTIC (Billy Minardi Classic) | FREEDOM HALL | WHAS | TBA |
| 12/24/05 | Sat | DETROIT | FREEDOM HALL | WHAS | 12:05 PM |
| 12/28/05 | Wed | FAIRLEIGH DICKINSON | FREEDOM HALL | WHAS | 7:05 PM |
| 12/31/05 | Sat | at Miami (MetroPCS Orange Bowl Classic) | Miami, Fla. | Fox Sports Net | 4:00 PM |
| 01/05/06 | Thu | VILLANOVA * | FREEDOM HALL | ESPN2 | 7:00 PM |
| 01/07/06 | Sat | at Providence * | Providence, R.I. | WBKI | 7:30 PM |
| 01/09/06 | Mon | UC DAVIS | FREEDOM HALL | WHAS | 8:05 PM |
| 01/15/06 | Sun | PITTSBURGH * | FREEDOM HALL | ESPN+/WHAS | 1:00 PM |
| 01/17/06 | Tue | at St. John's * | New York, N.Y. | ESPN2 | 9:00 PM |
| 01/21/06 | Sat | CONNECTICUT * | FREEDOM HALL | ESPN | 9:00 PM |
| 01/25/06 | Wed | CINCINNATI * | FREEDOM HALL | ESPN2 | 7:30 PM |
| 01/28/06 | Sat | at Rutgers * | Piscataway, N.J. | ESPN | 2:00 PM |
| 01/30/06 | Mon | at Villanova * | Philadelphia, Pa. | ESPN | 7:00 PM |
| 02/04/06 | Sat | NOTRE DAME * | FREEDOM HALL | ESPN | 12:00 PM |
| 02/06/06 | Mon | at Cincinnati * | Cincinnati, Ohio | ESPN2 | 7:00 PM |
| 02/11/06 | Sat | USF * | FREEDOM HALL | ESPN+/WHAS | 12:00 PM |
| 02/18/06 | Sat | at Syracuse * | Syracuse, N.Y. | ESPN | 8:00 PM |
| 02/22/06 | Wed | DEPAUL * | FREEDOM HALL | ESPNU | 9:00 PM |
| 02/25/06 | Sat | at West Virginia * | Morgantown, W.V. | CBS | 1:30 PM |
| 03/01/06 | Wed | MARQUETTE * | FREEDOM HALL | WHAS | 7:05 PM |
| 03/04/06 | Sat | at Connecticut * | Storrs, Conn. | CBS | 2:00 PM |
| 03/08/06 | Wed | at BIG EAST Conference Tournament | New York, N.Y. | TBA | TBA |
| 03/09/06 | Thu | at BIG EAST Conference Tournament | New York, N.Y. | TBA | TBA |
| 03/10/06 | Fri | at BIG EAST Conference Tournament | New York, N.Y. | TBA | TBA |
| 03/11/06 | Sat | at BIG EAST Conference Tournament | New York, N.Y. | TBA | TBA |
* Denotes Big East Conference game
Note:WHAS-TV (Channel 11) is an ABC network affiliate in Louisville. All U of L games are broadcast on the U of L Sports Radio Network, which originates on WHAS Radio (840 AM), a 50,000-watt clear-channel station in Louisville.
