| 11-03-2005 | Thu | Dalhousie (exh.) | Lexington, Ky. | W, 90-34 |
| 11-10-2005 | Thu | OGBM (exh.) | Lexington, Ky. | W, 84-44 |
| 11-18-2005 | Fri | IUPUI | Lexington, Ky. | 07:00 pm |
| 11-22-2005 | Tue | Stetson | Lexington, Ky. | 07:00 pm |
| 11-25-2005 | Fri | Indiana State | Malibu, Calif. | TBA |
| 11-26-2005 | Sat | TBD | Malibu, Calif. | TBA |
| 12-01-2005 | Thu | Florida International | Lexington, Ky. | 07:00 pm |
| 12-06-2005 | Tue | North Carolina A&T | Lexington, Ky. | 07:00 pm |
| 12-08-2005 | Thu | Georgetown Univ. (BBSN) | Lexington, Ky. | 07:00 pm |
| 12-10-2005 | Sat | Univ. of Detroit Mercy | Detroit, Mich. | 02:00 pm |
| 12-18-2005 | Sun | LSU (RSN) | Lexington, Ky. | 01:00 pm |
| 12-22-2005 | Thu | Tennessee State | Lexington, Ky. | 07:00 pm |
| 12-28-2005 | Wed | Louisville (Rupp Arena) (BBSN) | Lexington, Ky. | 07:00 pm |
| 12-31-2005 | Sat | Wake Forest | Winston-Salem, N.C. | 01:00 pm |
| 01-02-2006 | Mon | Bowling Green State | Lexington, Ky. | 07:00 pm |
| 01-08-2006 | Sun | South Carolina (BBSN) | Lexington, Ky. | 01:00 pm |
| 01-12-2006 | Thu | Florida | Gainesville, Fla. | 07:00 pm |
| 01-15-2006 | Sun | Georgia Tech (RSN) | Duluth, Ga. | 12:30 pm |
| 01-19-2006 | Thu | Auburn (Rupp Arena) | Lexington, Ky. | 07:00 pm |
| 01-22-2006 | Sun | Ole Miss | Oxford, Miss. | 03:00 pm |
| 01-26-2006 | Thu | Tennessee (Rupp Arena) (BBSN) | Lexington, Ky. | 07:00 pm |
| 02-02-2006 | Thu | Georgia | Athens, Ga. | 07:00 pm |
| 02-05-2006 | Sun | Florida (RSN) | Lexington, Ky. | 12:00 pm |
| 02-09-2006 | Thu | South Carolina | Columbia, S.C. | 07:00 pm |
| 02-12-2006 | Sun | Arkansas (RSN) | Fayetteville, Ark. | 03:00 pm |
| 02-16-2006 | Thu | Ole Miss | Lexington, Ky. | 07:00 pm |
| 02-19-2006 | Sun | Mississippi State | Starkville, Miss. | 03:00 pm |
| 02-23-2006 | Thu | Vanderbilt | Nashville, Tenn. | 08:00 pm |
| 02-26-2006 | Sun | Alabama (Rupp Arena) (RSN/BBSN) | Lexington, Ky. | 01:00 pm |
| 03-02-2006 | Thu | SEC Tournament | North Little Rock, Ark. | TBA |
| 03-03-2006 | Fri | SEC Tournament | North Little Rock, Ark. | TBA |
| 03-04-2006 | Sat | SEC Tournament | North Little Rock, Ark. | TBA |
| 03-05-2006 | Sun | SEC Tournament | North Little Rock, Ark. | TBA |
RSN - FOX Sports Net South, Fox Sports Net Southwest, Sun Sports
