Dino Dan follows the adventures of the paleontologist-in-training Dan Henderson and his friends, who uncover clues about the past and secrets of the dinosaurs. The show combines live action with CGI dinosaurs.

10 year old Dan Henderson learns about dinosaurs as he conducts experiments on dinosaurs he sees in his environment. Though they appear to be the result of his active imagination, some animals have also seen them, such as his dog, and in the episode Dino Trackers, Dan's younger brother can also see the dinosaur tracks.